Yes there is a way to load Diablo II LOD Expansion on your Mac with no CD. It requires using Disk Copy in OS X Jaguar. I am using it and it works great. When you open it go to the file menu and click on New. It will ask what source and navigate to "Image from device," from there locate your D2 LOD CD, name it exactly as your D2 CD and it will create a .dmg file of it. When made, eject your CD and double click on the D2 LoD .dmg file and it will create a HD image of your CD. Once done, just launch D2 and whala, Mac OS X instant CD crack.
If you care to delve deeper into the inner workings of D2 LoD on Mac OS X, then here is a great place to start.
http://mpqtoolforum.coucou.net/ This is a Mod macker utility that may have map hacking embedded into it.
Good Luck!
:rollie