That's just quotient rule. Derivative of the top function times the bottom function (top function, by power rule, goes from ^(1/2) to ^(-1/2), that's why it is on the top of the x(x^3-1) (the x comes from a chain rule of the top function). The 2nd half of the quotient rule is you subtract the derivative of the bottom multiplied by the top function. This is all over the bottom function squared.
They then simplify by multiplying by (x^2+4)^(1/2)/(x^2+4)^(1/2). And then they multiply and combine like terms.